This session explores how chemical plants can achieve safe, reliable, and resilient operations by integrating OSHA PSM practices (including hazard analysis and LOPA), Safety Instrumented Systems to close protection gaps, and defense-in-depth industrial cybersecurity to protect IT/OT control environments. Attendees will review practical frameworks that reduce cyber and process-safety risk while maintaining production and data integrity, strengthening compliance, decision-making, and long-term operational resilience.